Public defence: Hafiz Wajahat Hassan
Hafiz Wajahat Hassan defended his thesis “In vivo monitoring of tissue oxygenation in response to a Mg-based biodegradable implant using NIR spectroscopy” for the PhD programme in Engineering Science.
Hafiz Wajahat Hassan defended his thesis “In vivo monitoring of tissue oxygenation in response to a Mg-based biodegradable implant using NIR spectroscopy” for the PhD programme in Engineering Science.
Trial lecture: "Vibrational Spectroscopy sensing in Medicine".
Ordinary opponents:
Leader of the public defense: Professor Astrid Oust Janbu, OsloMet
Supervisors:
In developed and developing countries, patients with bone fractures suffer severe physical disabilities and quality of life impairments. Over the past few decades, magnesium (Mg) has been recognized as one of the third-generation biomaterials for supporting and regenerating bone tissues. Compared to permanent implants such as titanium and stainless steel, magnesium and its alloys are biodegradable and do not require a second surgery to be removed after bone tissue recovery.
In clinical applications, Mg alloys possess unique qualities that make them useful as biodegradable implants. However, it is challenging to assess Mg corrosion in a physiological environment via in vitro or in vivo techniques. Monitoring the degradation process throughout the process is challenging.
This thesis aims to investigate the monitoring of biodegradable implants in vitro and in vivo using a novel near-infrared (NIR) optical probe. As part of our analysis, we developed a set of experimental results for representing Mg degradation at various levels. In order to obtain information about the structural and functional properties of the implant-tissue interface, we conducted in vitro and in vivo experiments.
Overall, some of the results obtained were able to be associated and validated with those obtained from ultrasound photoacoustics. A combination of NIR spectroscopy and principal component analysis PCA can provide a more accurate assessment of tissue parameters. Furthermore, NIRS can provide insight into the tissue hemodynamics and degradation layer effects around the implant noninvasively.