About
Marissa Maciej-Hulme develops new and original methods to purify and interrogate glycoproteins, proteoglycans and glycan structures using a combination of CRISPR editing, molecular techniques, enzyme, and chemical preparations, as well as mass spectrometry analysis from biological fluids (eg. plasma, urine), cells and tissues that afford new insights into their biology.
Glycoproteins: https://improglyco.science/
Proteoglycans: https://www.proteoglycan-lab.com/
Research groups
Research projects
Ongoing research projects
-
Inhibitor-Mediated Programming of Glycoforms (IMProGlyco)
We will develop methods for altering the naturally occurring carbohydrate surface (so-called glycocalyx) found on all the cell's surfaces in humans.
Completed research projects
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Integrated Glycomics for Cancer Precision Medicine (GlycoMap)
This project will investigate organoids and new glycomics methods for cancer precision medicine.
Publications and research
Scientific publications
Rustad, Cecilie F.; Backe, Paul Hoff; Jin, Chunsheng; Merckoll, Else; Tveten, Kristian;
Maciej-Hulme, Marissa Lucy
;
Karlsson, Niclas
; Prescott, Trine; Sandås, Elise Mørk; Woldseth, Berit; Elgstøen, Katja B. Prestø; Holla, Øystein Lunde
(2024).
A monoallelic UXS1 variant associated with short-limbed short stature.
Molecular Genetics & Genomic Medicine.
Vol. 12.
https://doi.org/10.1002/mgg3.2472
Acharya, Binayak;
Tofthagen, Marthe
;
Maciej-Hulme, Marissa Lucy
; Suissa, Michal Rachel;
Karlsson, Niclas
(2024).
Limited support for a direct connection between prebiotics and intestinal permeability – a systematic review.
Glycoconjugate Journal.
https://doi.org/10.1007/s10719-024-10165-8
Kim, DooLi; Margalef, Maria;
Maciej-Hulme, Marissa Lucy
; Kellenbach, Edwin; Graaf, Mark de; Stamatialis, Dimitrios; Vlag, Johan van der
(2024).
Mixed matrix membranes with incorporated glycosaminoglycans have good blood biocompatibility combined to high toxin removal.
Journal of Membrane Science.
Vol. 699.
https://doi.org/10.1016/j.memsci.2024.122669
