Affiliation
Marissa Maciej-Hulme develops new and original methods to purify and interrogate glycoproteins, proteoglycans and glycan structures using a combination of CRISPR editing, molecular techniques, enzyme, and chemical preparations, as well as mass spectrometry analysis from biological fluids (eg. plasma, urine), cells and tissues that afford new insights into their biology.
Glycoproteins: https://improglyco.science/
Proteoglycans: https://www.proteoglycan-lab.com/
Research projects
Active research projects
Inhibitor-Mediated Programming of Glycoforms (IMProGlyco)
We will develop methods for altering the naturally occurring carbohydrate surface (so-called glycocalyx) found on all the cell's surfaces in humans.
Completed research projects
Integrated Glycomics for Cancer Precision Medicine (GlycoMap)
This project will investigate organoids and new glycomics methods for cancer precision medicine.
Publications and research
Scientific publications (5)
- Maciej-Hulme, Marissa; Kim, Jandi; Roberts, Elijah T.; Zhang, Yiqing; Velden, Anouk van der; Braanker, Dirk Den; Yanginlar, Cansu; Graaf, Mark de; Rabelink, Ton; Berg, Bernard van Den; Ommen, Ellen van; Maas, Rutger; Logt, Anne Els van de; Amster, I. Jonathan; Vlag, Johan van der (2026). Glycoinformatic Profiling of Label-Free Intact Heparan Sulfate Oligosaccharides. Molecular & Cellular Proteomics. Vol. 25
- Lisacek, Frederique; Hackett, William E.; Thaysen-Andersen, Morten; Karlsson, Niclas; Klein, Joshua; Kolarich, Daniel; Maciej-Hulme, Marissa; Okuda, Shujiro; Packer, Nicolle H.; Struwe, Weston B.; Takahashi, Yushi; Tiemeyer, Michael; Zaia, Joseph; Aoki-Kinoshita, Kiyoko F.; Kettner, Carsten (2025). Update and New Implementation of the MIRAGE Reporting Guidelines for Mass Spectrometry Experiments in Glycoscience. Molecular & Cellular Proteomics. Vol. 25. p. 101473-101473
- Rustad, Cecilie F.; Backe, Paul Hoff; Jin, Chunsheng; Merckoll, Else; Tveten, Kristian; Maciej-Hulme, Marissa Lucy; Karlsson, Niclas; Prescott, Trine; Sandås, Elise Mørk; Woldseth, Berit; Elgstøen, Katja B. Prestø; Holla, Øystein Lunde (2024). A monoallelic UXS1 variant associated with short-limbed short stature. Molecular Genetics & Genomic Medicine. Vol. 12. p. 1-14
- Acharya, Binayak; Tofthagen, Marthe; Maciej-Hulme, Marissa Lucy; Suissa, Michal Rachel; Karlsson, Niclas (2024). Limited support for a direct connection between prebiotics and intestinal permeability – a systematic review. Glycoconjugate Journal
- Kim, DooLi; Margalef, Maria; Maciej-Hulme, Marissa Lucy; Kellenbach, Edwin; Graaf, Mark de; Stamatialis, Dimitrios; Vlag, Johan van der (2024). Mixed matrix membranes with incorporated glycosaminoglycans have good blood biocompatibility combined to high toxin removal. Journal of Membrane Science. Vol. 699
These publications are obtained from Norwegian Research Information Repository. The list may be incomplete.