Tilhørighet
Mani underviser i anatomi, fysiologi, biokjemi og sykdomslære for studenter ved bachelorstudiet i sykepleie ved OsloMet. Hans akademiske interesser inkluderer hjerte- og karsykdommer og forebyggende medisin.
Cand.med. Universitetet i Oslo (2016)
Ph.D. Universitetet i Oslo (2023)
Fagfelt
Forskningsprosjekter
Aktive forskningsprosjekter
Kan tilbakemelding om forventet levealder forbedre etterlevelse av kosthold?
Kan tilbakemelding om hvor mange leveår sunnere kosthold kan gi, øke etterlevelsen av kostrådene? En pilotstudie tester dette i en digital, KI-assistert kostholdstjeneste.
Publikasjoner og forskningsresultater
Vitenskapelige publikasjoner (10)
- Andreassen, Kristine; Rixon, Chloe Louise; Haugsten, Marie Hansen; Hauge-Iversen, Ida Marie; Zhang, Lili; Sadredini, Mani; Erusappan, Pugazendhi Murugan; Sjaastad, Ivar; Christensen, Geir; Haugaa, Kristina Ingrid Helena Hermann; Edvardsen, Thor; Lunde, Ida Gjervold; Stokke, Mathis Korseberg (2023). Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice. American Journal of Physiology. Heart and Circulatory Physiology. Vol. 324. s. H881-H892
- Haugsten, Marie Hansen; Sadredini, Mani; Hasic, Almira; Eriksen, Morten; Stokke, Mathis Korseberg (2023). Myocardial oxidative stress is increased in early reperfusion, but systemic antioxidative therapy does not prevent ischemia-reperfusion arrhythmias in pigs. Frontiers in Cardiovascular Medicine. Vol. 10
- Haugsten, Marie Hansen; Sadredini, Mani; Hasic, Almira; Anderson, Mark E.; Sjaastad, Ivar; Stokke, Mathis Korseberg (2022). CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKIIδ at methionines 281/282 is not a determining factor. Journal of Molecular and Cellular Cardiology. Vol. 175. s. 49-61
- Sadredini, Mani; Manotheepan, Ravinea; Lehnart, Stephan E.; Anderson, Mark E.; Sjaastad, Ivar; Stokke, Mathis K. (2021). The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1. Physiological Reports. Vol. 9
- Sadredini, Mani; Haugsten, Marie Hansen; Frisk, Michael; Louch, William E.; Lehnart, Stephan E.; Sjaastad, Ivar; Stokke, Mathis Korseberg (2021). CaMKII inhibition has dual effects on spontaneous Ca<sup>2+</sup>release and Ca<sup>2+</sup> alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation. American Journal of Physiology. Heart and Circulatory Physiology. Vol. 321. s. H446-H460
- Danielsen, Tore Kristian; Sadredini, Mani; Manotheepan, Ravinea; Aronsen, Jan Magnus; Frisk, Michael; Haugsten, Marie Hansen; Andressen, Kjetil Wessel; Hougen, Karina; Levy, Finn Olav; Louch, William Edward; Sejersted, Ole M; Sjaastad, Ivar; Stokke, Mathis Korseberg (2021). Exercise training stabilizes RyR2-dependent Ca2+ release in post-infarction heart failure. Frontiers in Cardiovascular Medicine. Vol. 7
- Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Eken, Olav Søvik; Sadredini, Mani; Myhre, Peder Langeland; Shen, Xin; Dalhus, Bjørn; Laver, Derek R.; Lunde, Per Kristian; Kurola, Jouni; Lunde, Marianne; Hoff, Jon Erik; Godang, Kristin; Sjaastad, Ivar; Pettilä, Ville; Stridsberg, Mats; Lehnart, Stephan E.; Edwards, Andrew; Lunde, Ida Gjervold; Omland, Torbjørn; Stokke, Mathis Korseberg; Christensen, Geir Arve; Røsjø, Helge; Louch, William Edward (2019). Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia. Circulation: Arrhythmia and Electrophysiology. Vol. 12
- Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani; Leren, Ida Skrinde; Edwards, Andrew; Vincent, Kevin P.; Lehnart, Stephan .; Sejersted, Ole M; Sjaastad, Ivar; Haugaa, Kristina; Stokke, Mathis Korseberg (2018). Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation. PLOS ONE. Vol. 13:e0207100. s. 1-21
- Sadredini, Mani; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Hougen, Karina; Sjaastad, Ivar; Stokke, Mathis Korseberg (2016). Beta-adrenoceptor stimulation reveals Ca2+ waves and sarcoplasmic reticulum Ca2+ depletion in left ventricular cardiomyocytes from post-infarction rats with and without heart failure. PLOS ONE. Vol. 11
- Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani; Anderson, Mark E.; Carlson, Cathrine Rein; Lehnart, Stefan; Sjaastad, Ivar; Stokke, Mathis Korseberg (2016). Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release. Cardiovascular Research (CVR). Vol. 111. s. 295-306
Formidling (26)
- Stojiljkovic, Marko; Kviserud, Kent Robert; Ziegler-Olsen, Martinius; Sadredini, Mani; Hovland, Olav Johannes (2025). Menn i sykepleie: et nettverk for økt rekruttering, inkludering og trivsel. Norsk Sykepleierforbund Oslos symposium
- Efstathiou, Sofia; Sadredini, Mani; Coutinho, Silvia Ribeiro (2022). MEAT meets! Mani Sadredini
- Sadredini, Mani; Manotheepan, Ravinea; Danielsen, Tore Kristian; Lehnart, Stefan; Sjaastad, Ivar; Stokke, Mathis Korseberg (2016). Epac2 inhibition reduces arrhythmogenic Ca2+ wave frequently in cardiomyocytes from mice With catecholaminergic polymorphic ventricular tachcardia type 1. 14th Annual CHFR Symposium
- Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani; Leren, I.S.; Edwards, Andrew; Vincent, K.; Lehnart, Stefan; Sejersted, Ole M; Sjaastad, Ivar; Haugaa, Kristina; Stokke, Mathis Korseberg (2016). Mechanisms underlying the frequency-dependence of triggered arrhythmias in catecholaminergic polymorphic ventricular tachycardia type 1. 14th Annual CHFR Symposium on Heart Failure
- Manotheepan, Ravinea; Danielsen, Tore Kristian; Saberniak, Jorg; Sadredini, Mani; Anderson, Mark e.; Carlson, Cathrine Rein; Edvardsen, Thor; Lehnart, Stefan; Sjaastad, Ivar; Haugaa, Kristina; Stokke, Mathis Korseberg (2016). Exercise training as anti-arrhythmic therapy in cathecholaminergic polymorphic ventricular tachycardia type 1. Norwegian Society of Cardiology, Autumn Meeting
- Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Anderson, Mark e.; Carlson, Cathrine Rein; Lehnart, Stefan; Sjaastad, Ivar; Stokke, Mathis Korseberg (2015). Exercise training reduced CaMKII-dependent arrhythmogenic Ca2+ release and prevents ventricular tachycardia in CPVT 1. 13th Annual CHFR Symposium on Heart Failure
- Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Hougen, Karina; Sjaastad, Ivar; Stokke, Mathis Korseberg (2015). Beta-adrenoreceptor stimulation reveals Ca2+ overload paradox in left ventricular cardiomyocytes from post-infarction rats with and without heart failure. 13th Annual CHFR Symposium on Heart Failure
- Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Gaur, Namit; Leren, IS; Edwards, Andrew; Sejersted, Ole M; Lehnart, Stefan; Sjaastad, Ivar; Haugaa, Kristina; Stokke, Mathis Korseberg (2015). Mechanisms for the frequency-dependence of triggered activity in catecholaminergic polymorphic ventricular tachycardia type 1. 13th Annual CHFR Meeting
- Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Hougen, Karina; Sjaastad, Ivar; Stokke, Mathis Korseberg (2015). Beta-adrenoceptor stimulation reveals Ca2+ overload paradox in left ventricular cardiomyocytes from post-infarction rats with and without heart failure. 7th National PhD Conference in Medical Imaging
- Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Hougen, Karina; Sejersted, Ole M; Sjaastad, Ivar; Stokke, Mathis Korseberg (2014). The effect of exercise training on Ca2+ wave probability after myocardial infarction varies with cardiac function at onset of training. 12th Annual Center for Heart Failure Symposium
- Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Lehnart, Stefan; Sjaastad, Ivar; Stokke, Mathis Korseberg (2014). Exercise training reduces CaMKII-dependent phosphorylation of the cardiac ryanodine receptor and arrhythmogenic SR Ca2+ leak in mice with mutant cardiac ryanodine receptor 2. National PhD Conference in Medical Imaging and MedViz Conference
- Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Anderson, Mark E.; Lehnart, Stephan; Sjaastad, Ivar; Stokke, Mathis Korseberg (2014). Exercise training reduces CaMKII-dependent phosphorylation of RyR2 and arrhythmogenic SR Ca2+ release in mince with CPVT. 12th Annual Center for Heart Failure Symposium
- Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Hougen, Karina; Sejersted, Ole M; Sjaastad, Ivar; Stokke, Mathis Korseberg (2013). The effect of exercise training on ca2+ wave probability after myocardial infarction depends on cardiac function at onset of training. Heart Rhythm. Vol. 10. s. 1749-1749
- Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Sjaastad, Ivar; Stokke, Mathis Korseberg (2013). Ca2+ wave probability is differently affected in cardiomyocytes from rats with failing and non-failing cardiac function after myocardial infarction. 37th Meeting of the European Working Groups on Cardiac Cellular Electrophysiology (EWGCCE)
- Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Lehnart, Stephan; Sjaastad, Ivar; Stokke, Mathis Korseberg (2013). Exercise training reduces Ca2+ -calmodulin-dependent protein kinase type II dependent phosphorylation of the cardiac ryanodine receptor and Ca2+ leak from the sarcoplasmic reticulum in mice with mutant cardiac ryanodine receptor. 11th Annual CHFR Symposium
- Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Lehnart, Stephen; Sjaastad, Ivar; Stokke, Mathis Korseberg (2013). Exercise training reduces Ca2+-calmodulin-dependent protein kinase type II dependent phosphorylation of the cardiac ryanodine receptor and Ca2+ leak from the sarcoplasmic reticulum in mice with mutant cardiac ryanodine receptor 2. Circulation. Vol. 128
- Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Lehnart, Stephan; Sjaastad, Ivar; Stokke, Mathis Korseberg (2013). Can exercise training prevent arrhythmogenic Ca2+ release in RyR2-R2474S mice?. 37th Meeting of the European Working Groups on Cardiac Cellular Electrophysiology
- Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Hougen, Karina; Sejersted, Ole M; Sjaastad, Ivar; Stokke, Mathis Korseberg (2013). The effect of exercise training on Ca2+ wave probability after myocardial infarction depends on cardiac function at onset of training. 37th Meeting of the European Working Groups on Cardiac Cellular Electrophysiology
- Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Hougen, Karina; Sejersted, Ole M; Sjaastad, Ivar; Stokke, Mathis Korseberg (2013). The effect of exercise training on Ca2+ wave probability after myocardial infarction depends on cardiac function at onset of training. 11th Annual CHFR Symposium
- Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Sjaastad, Ivar; Stokke, Mathis Korseberg (2013). Ca2+ wave probability is differently affected in cardiomyocytes from rats with failing and non-failing cardiac function after myocardial infarction. 11th Annual CHFR Symposium
- Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Sjaastad, Ivar; Stokke, Mathis Korseberg (2012). Ca2+ wave probability in rats with varying levels of cardiac contractile dysfunction after myocardial infarction. 10th Annual CHFR Symposium
- Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Sjaastad, Ivar; Stokke, Mathis Korseberg (2012). Ca2+ wave probability in rats with varying levels of cardiac contractile dysfunction after myocardial infarction. Scandinavian Physiological Society Annual Meeting
- Loose, Kristian; Sadredini, Mani Nikoo; Sejersted, Ole M; Stokke, Mathis Korseberg; Louch, William Edward (2012). Ca2+ wave velocity in cardiomyocytes is regulated by ryanodine receptor Ca2+ sensitivity and SR Ca2+ content. 10th Annual CHFR Symposium
- Loose, Kristian; Sadredini, Mani Nikoo; Sejersted, Ole M; Stokke, Mathis Korseberg; Louch, William Edward (2012). Ca2+ wave velocity in cardiomyocytes is regulated by ryanodine receptor Ca2+ sensitivity and SR 2+ content. Biophysical Journal. Vol. 102. s. 99a-100a
- Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Sejersted, Ole M; Sjaastad, Ivar; Stokke, Mathis Korseberg (2012). Short-term protocols are sufficient to induce exercise effects in rodents. 10th Annual CHFR Symposium
- Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Sjaastad, Ivar; Stokke, Mathis Korseberg (2012). Ca2+ wave probability in rats with varying levels of cardiac contractile dysfunction after myocardial infarction. 36th Meeting of the European Working Group on Cardiac Cellular Electrophysiology
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