This project is an assessment of variation in exposure and response to psychoactive drugs.
Patients on psychoactive drugs respond differently to the same medication given in the same dose.
There are numerous reasons for this, including physiological differences, lifestyle factors, the use of other medications, and genetically determined variations in enzymes that metabolize these drugs (pharmacogenetics).
In this project we investigate the causes of variation in drug response (efficacy/side effects) and how clinical practice can be tailored to the individual patients based on knowledge of these respective causes.
Our main focus is on identifying genetic markers as well as biological molecules in blood (biomarkers) that can predict drug effectiveness before treatment.
Karolinska Institute, Department of Physiology and Pharmacology, Sweden.