The goal of this project is to develop a 3D human foetal testis organoid model to investigate how testicular cancer initiates. We plan to investigate the role of risk genes in the development of the disease, and which role environmental factors may have.
Testicular cancer is the most common malignancy in young men in large parts of the world. Its rising incidence is linked to both genetic predisposition and environmental factors. Progress in understanding its origins has been limited by the lack of suitable models.
This project aims to develop a human foetal testis organoid model that mimics the cellular composition and environment of the developing testis. Containing Sertoli cells, Leydig cells and gonocytes – the precursor cells of testicular cancer – this model will enable mechanistic studies of genetic susceptibility and environmental influences on testicular cancer development.
This project has received funding from OsloMet's technology and health initiative Intelligent Health.
