Affiliation
Professor Niclas Karlsson’s research is focusing on the role of glycosylation in human health. Glycans are omnipresent in biological interfaces, including the glycocalyx on cell membranes, on mucosal surfaces that protects gastrointestinal, pulmonary and reproductive tracts and the joints in the muscoskeletal system. The group is applying state-of-the-art mass spectrometric and HPLC based glycomics and glycoproteomics of both N-linked and O-linked glycoproteins to identify pathological alteration of the glycosylation.
Databases:
UniCarb-DB (https://unicarb-db.expasy.org)
UniCarb-DR (https://unicarb-dr.glycosmos.org).
Publications:
Pubmed (https://www.ncbi.nlm.nih.gov/myncbi/1-Wzd4_y7_JkD/bibliography/public/)
Twitter: UniCarb-DB@NG_Karlsson
Research projects
Active research projects
Glyco-pathology in dry eye disease
The PhD project investigates how ocular mucin-proteins, and their glycosylation maintain a healthy tear film, while exploring their contribution to the development and progression of dry eye disease.
Inhibitor-Mediated Programming of Glycoforms (IMProGlyco)
We will develop methods for altering the naturally occurring carbohydrate surface (so-called glycocalyx) found on all the cell's surfaces in humans.
Completed research projects
Lacritin-incorporated nanoparticles as new and improved treatment of dry eye disease
We are developing the protein lacritin, which is found in tears, to become a medicine for dry eye disease.
Integrated Glycomics for Cancer Precision Medicine (GlycoMap)
This project will investigate organoids and new glycomics methods for cancer precision medicine.