About
Professor Niclas Karlsson’s research is focusing on the role of glycosylation in human health. Glycans are omnipresent in biological interfaces, including the glycocalyx on cell membranes, on mucosal surfaces that protects gastrointestinal, pulmonary and reproductive tracts and the joints in the muscoskeletal system. The group is applying state-of-the-art mass spectrometric and HPLC based glycomics and glycoproteomics of both N-linked and O-linked glycoproteins to identify pathological alteration of the glycosylation.
Databases:
UniCarb-DB (https://unicarb-db.expasy.org)
UniCarb-DR (https://unicarb-dr.glycosmos.org).
Publications:
Pubmed (https://www.ncbi.nlm.nih.gov/myncbi/1-Wzd4_y7_JkD/bibliography/public/)
Twitter: UniCarb-DB@NG_Karlsson
Research groups
Research projects
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Lacritin-incorporated nanoparticles as new and improved treatment of dry eye disease
We are developing the protein lacritin, which is found in tears, to become a medicine for dry eye disease.
Publications and research
Scientific publications
Saldova, Radka; Thomsson, Kristina A.; Wilkinson, Hayden; Chatterjee, Maitrayee; Singh, Ashish K.;
Karlsson, Niclas
; Knaus, Ulla G.
(2024).
Characterization of intestinal O-glycome in reactive oxygen species deficiency.
PLOS ONE.
Vol. 19.
https://doi.org/10.1371/journal.pone.0297292
Bechtella, Leïla; Chunsheng, Jin; Fentker, Kerstin; Ertürk, Güney R.; Safferthal, Marc; Polewski, Łukasz; Götze, Michael; Graeber, Simon Y.; Vos, Gaël M.; Struwe, Weston B.; Mall, Marcus A.; Mertins, Philipp;
Karlsson, Niclas
; Pagel, Kevin
(2024).
Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Nature Communications.
Vol. 15.
https://doi.org/10.1038/s41467-024-46825-4
Elsaid, Khaled; Merriman, Tony R.; Rossitto, Leigh-Ana; Liu-Bryan, Ru; Karsh, Jacob; Phipps-Green, Amanda; Jay, Gregory D.; Elsayed, Sandy; Qadri, Marwa; Miner, Marin; Cadzow, Murray; Dambruoso, Talia J.; Schmidt, Tannin A.; Dalbeth, Nicola; Chhana, Ashika; Höglund, Jennifer; Ghassemian, Majid; Campeau, Anaamika; Maltez, Nancy;
Karlsson, Niclas
; Gonzalez, David J.; Terkeltaub, Robert
(2023).
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Arthritis & Rheumatology.
Vol. 75.
https://doi.org/10.1002/art.42413
De Marco Verissimo, Carolina; Cwiklinski, Krystyna; Nilsson, Jonas; Mirgorodskaya, Ekaterina; Jin, Chunsheng;
Karlsson, Niclas
; Dalton, John P.
(2023).
Glycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica.
Molecular & Cellular Proteomics.
Vol. 22.
https://doi.org/10.1016/j.mcpro.2023.100684
Andersson, Elin; Tykesson, Emil; Lohmander, L. Stefan;
Karlsson, Niclas
; Jin, Chunsheng; Mirgorodskaya, Ekaterina; Swärd, Per; Struglics, André
(2023).
Quantification of chondroitin sulfate, hyaluronic acid and N-glycans in synovial fluid – A technical performance study.
Osteoarthritis and Cartilage Open.
Vol. 5.
https://doi.org/10.1016/j.ocarto.2023.100380
Contessotto, Paolo; Spelat, Renza; Ferro, Federico; Vysockas, Vaidas; Krivickienė, Aušra; Jin, Chunsheng; Chantepie, Sandrine; Chinello, Clizia; Pauza, Audrys G.; Valente, Camilla; Rackauskas, Mindaugas; Casara, Alvise; Zigmantaitė, Vilma; Magni, Fulvio; Papy-Garcia, Dulce;
Karlsson, Niclas
; Ereminienė, Eglė; Pandit, Abhay; Da Costa, Mark
(2023).
Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model.
16 p.
Nature Communications.
Vol. 14.
https://doi.org/10.1038/s41467-023-36350-1
Chahal, Gurdeep; Padra, Médea; Erhardsson, Mattias; Jin, Chunsheng; Quintana-Hayashi, Macarena; Venkatakrishnan, Vignesh; Padra, János Tamás; Stenbäck, Helen; Thorell, Anders;
Karlsson, Niclas
; Lindén, Sara K.
(2022).
A Complex Connection Between the Diversity of Human Gastric Mucin O-Glycans, Helicobacter pylori Binding, Helicobacter Infection and Fucosylation.
Molecular & Cellular Proteomics.
Vol. 21.
https://doi.org/10.1016/j.mcpro.2022.100421
Huang, Shan; Thomsson, Kristina A.; Jin, Chunsheng; Ryberg, Henrik; Das, Nabangshu; Struglics, André; Rolfson, Ola; Björkman, Lena I.; Eisler, Thomas; Schmidt, Tannin A.; Jay, Gregory D.; Krawetz, Roman;
Karlsson, Niclas
(2022).
Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines.
Frontiers in Molecular Biosciences.
Vol. 9.
https://doi.org/10.3389/fmolb.2022.942406
Luis, Ana S; Baslé, Arnaud; Byrne, Dominic P.; Wright, Gareth S. A.; London, James A.; Jin, Chunsheng;
Karlsson, Niclas
; Hansson, Gunnar C.; Eyers, Patrick A.; Czjzek, Mirjam; Barbeyron, Tristan; Yates, Edwin A.; Martens, Eric C.; Cartmell, Alan
(2022).
Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota.
8 p.
Nature Chemical Biology.
Vol. 18.
https://doi.org/10.1038/s41589-022-01039-x
Kouka, Thukaa; Akase, Sachiko; Sogabe, Isami; Jin, Chunsheng;
Karlsson, Niclas
; Aoki-Kinoshita, Kiyoko F.
(2022).
Computational Modeling of O-Linked Glycan Biosynthesis in CHO Cells.
Molecules.
Vol. 27.
https://doi.org/10.3390/molecules27061766
