About
Professor Niclas Karlsson’s research is focusing on the role of glycosylation in human health. Glycans are omnipresent in biological interfaces, including the glycocalyx on cell membranes, on mucosal surfaces that protects gastrointestinal, pulmonary and reproductive tracts and the joints in the muscoskeletal system. The group is applying state-of-the-art mass spectrometric and HPLC based glycomics and glycoproteomics of both N-linked and O-linked glycoproteins to identify pathological alteration of the glycosylation.
Databases:
UniCarb-DB (https://unicarb-db.expasy.org)
UniCarb-DR (https://unicarb-dr.glycosmos.org).
Publications:
Pubmed (https://www.ncbi.nlm.nih.gov/myncbi/1-Wzd4_y7_JkD/bibliography/public/)
Twitter: UniCarb-DB@NG_Karlsson
Research groups
Publications and research
Scientific publications
Chahal, Gurdeep; Padra, Médea; Erhardsson, Mattias; Jin, Chunsheng; Quintana-Hayashi, Macarena; Venkatakrishnan, Vignesh; Padra, János Tamás; Stenbäck, Helen; Thorell, Anders; Karlsson, Niclas; Lindén, Sara K. (2022). A Complex Connection Between the Diversity of Human Gastric Mucin O-Glycans, Helicobacter pylori Binding, Helicobacter Infection and Fucosylation. Molecular & Cellular Proteomics . Vol. 21.
Huang, Shan; Thomsson, Kristina A.; Jin, Chunsheng; Ryberg, Henrik; Das, Nabangshu; Struglics, André; Rolfson, Ola; Björkman, Lena I.; Eisler, Thomas; Schmidt, Tannin A.; Jay, Gregory D.; Krawetz, Roman; Karlsson, Niclas (2022). Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines. Frontiers in Molecular Biosciences . Vol. 9.
Luis, Ana S; Baslé, Arnaud; Byrne, Dominic P.; Wright, Gareth S. A.; London, James A.; Jin, Chunsheng; Karlsson, Niclas; Hansson, Gunnar C.; Eyers, Patrick A.; Czjzek, Mirjam; Barbeyron, Tristan; Yates, Edwin A.; Martens, Eric C.; Cartmell, Alan (2022). Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Nature Chemical Biology . Vol. 18.
Kouka, Thukaa; Akase, Sachiko; Sogabe, Isami; Jin, Chunsheng; Karlsson, Niclas; Aoki-Kinoshita, Kiyoko F. (2022). Computational Modeling of O-Linked Glycan Biosynthesis in CHO Cells. Molecules . Vol. 27.
Wilkinson, Hayden; Thomsson, Kristina A.; Rebelo, Ana L.; Hilliard, Mark; Pandit, Abhay; Rudd, Pauline M.; Karlsson, Niclas; Saldova, Radka (2021). The O-Glycome of Human Nigrostriatal Tissue and Its Alteration in Parkinson's Disease. Journal of Proteome Research . Vol. 20.
Mateoui, Constantina; Vitiazeva, Varvara; Kristjansdottir, Björg; Weijdegård, Birgitta; Örnros, Jessica; Gallini, Radiosa; Kamali-Moghaddam, Masood; Sundfeldt, Karrin; Karlsson, Niclas (2021). Analysis of blood group antigens on MUC5AC in mucinous ovarian cancer tissues using in situ proximity ligation assay. Glycobiology . Vol. 31.
Aoki-Kinoshita, Kiyoko F.; Lisacek, Frederique; Karlsson, Niclas; Kolarich, Daniel; Packer, Nicolle H. (2021). GlycoBioinformatics. Beilstein Journal of Organic Chemistry . Vol. 17.
Thomsson, Kristina A.; Vitiazeva, Varvara; Mateoiu, Constantina; Jin, Chunsheng; Liu, Jining; Holgersson, Jan; Weijdegård, Birgitta; Sundfeldt, Karin; Karlsson, Niclas (2021). Sulfation of O-glycans on mucin-type proteins from serous ovarian epithelial tumors. 17 p. Molecular & Cellular Proteomics . Vol. 20.
