Niclas Karlsson

About

Professor Niclas Karlsson’s research is focusing on the role of glycosylation in human health. Glycans are omnipresent in biological interfaces, including the glycocalyx on cell membranes, on mucosal surfaces that protects gastrointestinal, pulmonary and reproductive tracts and the joints in the muscoskeletal system. The group is applying state-of-the-art mass spectrometric and HPLC based glycomics and glycoproteomics of both N-linked and O-linked glycoproteins to identify pathological alteration of the glycosylation.

Databases:

UniCarb-DB (https://unicarb-db.expasy.org)

UniCarb-DR (https://unicarb-dr.glycosmos.org).

Publications:

Pubmed (https://www.ncbi.nlm.nih.gov/myncbi/1-Wzd4_y7_JkD/bibliography/public/)

Twitter: UniCarb-DB@NG_Karlsson

Research groups

Research projects

Ongoing research projects

Glyco-pathology in dry eye disease
The PhD project investigates how ocular mucin-proteins, and their glycosylation maintain a healthy tear film, while exploring their contribution to the development and progression of dry eye disease.
Inhibitor-Mediated Programming of Glycoforms (IMProGlyco)
We will develop methods for altering the naturally occurring carbohydrate surface (so-called glycocalyx) found on all the cell's surfaces in humans.

Completed research projects

Integrated Glycomics for Cancer Precision Medicine (GlycoMap)
This project will investigate organoids and new glycomics methods for cancer precision medicine.
Lacritin-incorporated nanoparticles as new and improved treatment of dry eye disease
We are developing the protein lacritin, which is found in tears, to become a medicine for dry eye disease.

Scientific publications

Afshari, Ali Reza ; Chang, Vincent; Thomsson, Kristina A.; Höglund, Jennifer; Browne, Elizabeth N.; Karadzhov, George; Mahoney, Keira E.; Lucas, Taryn M.; Rangel-Angarita, Valentina; Ryberg, Henrik; Gidwani, Kamlesh; Pettersson, Kim; Rolfson, Ola; Björkman, Lena I.; Eisler, Thomas; Schmidt, Tannin A.; Jay, Gregory D.; Malaker, Stacy A.; Karlsson, Niclas (2025). Glycoproteoforms of Osteoarthritis-associated Lubricin in Plasma and Synovial Fluid. Molecular & Cellular Proteomics. Vol. 24.
https://doi.org/10.1016/j.mcpro.2025.100923

Bechtella, Leïla; Chunsheng, Jin; Fentker, Kerstin; Ertürk, Güney R.; Safferthal, Marc; Polewski, Łukasz; Götze, Michael; Graeber, Simon Y.; Vos, Gaël M.; Struwe, Weston B.; Mall, Marcus A.; Mertins, Philipp; Karlsson, Niclas ; Pagel, Kevin (2024). Ion mobility-tandem mass spectrometry of mucin-type O-glycans. Nature Communications. Vol. 15.
https://doi.org/10.1038/s41467-024-46825-4

Urban, James; Jin, Chunsheng; Thomsson, Kristina A.; Karlsson, Niclas ; Ives, Callum M.; Fadda, Elisa; Bojar, Daniel (2024). Predicting glycan structure from tandem mass spectrometry via deep learning. Nature Methods. Vol. 21.
https://doi.org/10.1038/s41592-024-02314-6

Saldova, Radka; Thomsson, Kristina A.; Wilkinson, Hayden; Chatterjee, Maitrayee; Singh, Ashish K.; Karlsson, Niclas ; Knaus, Ulla G. (2024). Characterization of intestinal O-glycome in reactive oxygen species deficiency. PLOS ONE. Vol. 19.
https://doi.org/10.1371/journal.pone.0297292

Swisa, Avital; Kieckhaefer, Julia; Daniel, Scott G.; El-Mekkoussi, Hilana; Kolev, Hannah M.; Tigue, Mark; Jin, Chunsheng; Assenmacher, Charles-Antoine; Dohnalová, Lenka; Thaiss, Christoph A.; Karlsson, Niclas ; Bittinger, Kyle; Kaestner, Klaus H. (2024). The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation. Developmental Cell.
https://doi.org/10.1016/j.devcel.2024.05.006

Takahashi, Yushi; Karlsson, Niclas ; Okuda, Shujiro; Aoki-Kinoshita, Kiyoko F. (2024). Cooperation of GlycoPOST and UniCarb-DR towards a comprehensive glycomics data repository workflow. Analytical and Bioanalytical Chemistry.
https://doi.org/10.1007/s00216-024-05673-3

Kamounah, Sarah; Thomsson, Kristina A.; Sørensen, Christiane Elisabeth; Bennett, Eric Paul; Karlsson, Niclas ; Pedersen, Anne Marie Lynge (2024). Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca. Scientific Reports. Vol. 14.
https://doi.org/10.1038/s41598-024-79473-1

Jin, Chunsheng; Venkatakrishnan, Vignesh; Thomsson, Kristina A.; Aoki, Nobuyuki P.; Shinmachi, Daisuke; Aoki-Kinoshita, Kiyoko F.; Hayes, Catherine A.; Lisacek, Frédérique; Karlsson, Niclas (2024). UniCarb-DB: An MS/MS Experimental Glycomic Fragmentation Database. Methods in molecular biology. Vol. 2836.
https://doi.org/10.1007/978-1-0716-4007-4_6

Rustad, Cecilie F.; Backe, Paul Hoff; Jin, Chunsheng; Merckoll, Else; Tveten, Kristian; Maciej-Hulme, Marissa Lucy ; Karlsson, Niclas ; Prescott, Trine; Sandås, Elise Mørk; Woldseth, Berit; Elgstøen, Katja B. Prestø; Holla, Øystein Lunde (2024). A monoallelic UXS1 variant associated with short-limbed short stature. Molecular Genetics & Genomic Medicine. Vol. 12.
https://doi.org/10.1002/mgg3.2472

Acharya, Binayak; Tofthagen, Marthe ; Maciej-Hulme, Marissa Lucy ; Suissa, Michal Rachel; Karlsson, Niclas (2024). Limited support for a direct connection between prebiotics and intestinal permeability – a systematic review. Glycoconjugate Journal.
https://doi.org/10.1007/s10719-024-10165-8

See all publications

These publications are obtained from Norwegian Research Information Repository. The list may be incomplete.