About
Professor Niclas Karlsson’s research is focusing on the role of glycosylation in human health. Glycans are omnipresent in biological interfaces, including the glycocalyx on cell membranes, on mucosal surfaces that protects gastrointestinal, pulmonary and reproductive tracts and the joints in the muscoskeletal system. The group is applying state-of-the-art mass spectrometric and HPLC based glycomics and glycoproteomics of both N-linked and O-linked glycoproteins to identify pathological alteration of the glycosylation.
Databases:
UniCarb-DB (https://unicarb-db.expasy.org)
UniCarb-DR (https://unicarb-dr.glycosmos.org).
Publications:
Pubmed (https://www.ncbi.nlm.nih.gov/myncbi/1-Wzd4_y7_JkD/bibliography/public/)
Twitter: UniCarb-DB@NG_Karlsson
Research groups
Research projects
Ongoing research projects
-
Glyco-pathology in dry eye disease
The PhD project investigates how ocular mucin-proteins, and their glycosylation maintain a healthy tear film, while exploring their contribution to the development and progression of dry eye disease.
-
Inhibitor-Mediated Programming of Glycoforms (IMProGlyco)
This project will establish robust protocols for site-directed mutagenesis of glycans in mammalian cells.
-
Integrated Glycomics for Cancer Precision Medicine (GlycoMap)
This project will investigate organoids and new glycomics methods for cancer precision medicine.
-
Lacritin-incorporated nanoparticles as new and improved treatment of dry eye disease
We are developing the protein lacritin, which is found in tears, to become a medicine for dry eye disease.
Publications and research
Scientific publications
Acharya, Binayak;
Tofthagen, Marthe
;
Maciej-Hulme, Marissa Lucy
; Suissa, Michal Rachel;
Karlsson, Niclas
(2024).
Limited support for a direct connection between prebiotics and intestinal permeability – a systematic review.
Glycoconjugate Journal.
https://doi.org/10.1007/s10719-024-10165-8
Rustad, Cecilie F.; Backe, Paul Hoff; Jin, Chunsheng; Merckoll, Else; Tveten, Kristian;
Maciej-Hulme, Marissa Lucy
;
Karlsson, Niclas
; Prescott, Trine; Mørk Sandås, Elise; Woldseth, Berit; Elgstøen, Katja B. Prestø; Holla, Øystein Lunde
(2024).
A monoallelic UXS1 variant associated with short-limbed short stature.
Molecular Genetics & Genomic Medicine.
Vol. 12.
https://doi.org/10.1002/mgg3.2472
Kamounah, Sarah; Thomsson, Kristina A.; Sørensen, Christiane Elisabeth; Bennett, Eric Paul;
Karlsson, Niclas
; Pedersen, Anne Marie Lynge
(2024).
Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca.
Scientific Reports.
Vol. 14.
https://doi.org/10.1038/s41598-024-79473-1
Takahashi, Yushi;
Karlsson, Niclas
; Okuda, Shujiro; Aoki-Kinoshita, Kiyoko F.
(2024).
Cooperation of GlycoPOST and UniCarb-DR towards a comprehensive glycomics data repository workflow.
Analytical and Bioanalytical Chemistry.
https://doi.org/10.1007/s00216-024-05673-3
Urban, James; Jin, Chunsheng; Thomsson, Kristina A.;
Karlsson, Niclas
; Ives, Callum M.; Fadda, Elisa; Bojar, Daniel
(2024).
Predicting glycan structure from tandem mass spectrometry via deep learning.
9 p.
Nature Methods.
Vol. 21.
https://doi.org/10.1038/s41592-024-02314-6
Jin, Chunsheng; Venkatakrishnan, Vignesh; Thomsson, Kristina A.; Aoki, Nobuyuki P.; Shinmachi, Daisuke; Aoki-Kinoshita, Kiyoko F.; Hayes, Catherine A.; Lisacek, Frédérique;
Karlsson, Niclas
(2024).
UniCarb-DB: An MS/MS Experimental Glycomic Fragmentation Database.
19 p.
Methods in molecular biology.
Vol. 2836.
https://doi.org/10.1007/978-1-0716-4007-4_6
Swisa, Avital; Kieckhaefer, Julia; Daniel, Scott G.; El-Mekkoussi, Hilana; Kolev, Hannah M.; Tigue, Mark; Jin, Chunsheng; Assenmacher, Charles-Antoine; Dohnalová, Lenka; Thaiss, Christoph A.;
Karlsson, Niclas
; Bittinger, Kyle; Kaestner, Klaus H.
(2024).
The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation.
Developmental Cell.
https://doi.org/10.1016/j.devcel.2024.05.006
Saldova, Radka; Thomsson, Kristina A.; Wilkinson, Hayden; Chatterjee, Maitrayee; Singh, Ashish K.;
Karlsson, Niclas
; Knaus, Ulla G.
(2024).
Characterization of intestinal O-glycome in reactive oxygen species deficiency.
PLOS ONE.
Vol. 19.
https://doi.org/10.1371/journal.pone.0297292
Bechtella, Leïla; Chunsheng, Jin; Fentker, Kerstin; Ertürk, Güney R.; Safferthal, Marc; Polewski, Łukasz; Götze, Michael; Graeber, Simon Y.; Vos, Gaël M.; Struwe, Weston B.; Mall, Marcus A.; Mertins, Philipp;
Karlsson, Niclas
; Pagel, Kevin
(2024).
Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Nature Communications.
Vol. 15.
https://doi.org/10.1038/s41467-024-46825-4
Elsaid, Khaled; Merriman, Tony R.; Rossitto, Leigh-Ana; Liu-Bryan, Ru; Karsh, Jacob; Phipps-Green, Amanda; Jay, Gregory D.; Elsayed, Sandy; Qadri, Marwa; Miner, Marin; Cadzow, Murray; Dambruoso, Talia J.; Schmidt, Tannin A.; Dalbeth, Nicola; Chhana, Ashika; Höglund, Jennifer; Ghassemian, Majid; Campeau, Anaamika; Maltez, Nancy;
Karlsson, Niclas
; Gonzalez, David J.; Terkeltaub, Robert
(2023).
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Arthritis & Rheumatology.
Vol. 75.
https://doi.org/10.1002/art.42413
