Norwegian version
Niclas Karlsson

Niclas Karlsson


Professor Niclas Karlsson’s research is focusing on the role of glycosylation in human health. Glycans are omnipresent in biological interfaces, including the glycocalyx on cell membranes, on mucosal surfaces that protects gastrointestinal, pulmonary and reproductive tracts and the joints in the muscoskeletal system. The group is applying state-of-the-art mass spectrometric and HPLC based glycomics and glycoproteomics of both N-linked and O-linked glycoproteins to identify pathological alteration of the glycosylation.


UniCarb-DB (

UniCarb-DR ( 


Pubmed (

Twitter: UniCarb-DB@NG_Karlsson

Research projects

Scientific publications

Saldova, Radka; Thomsson, Kristina A.; Wilkinson, Hayden; Chatterjee, Maitrayee; Singh, Ashish K.; Karlsson, Niclas ; Knaus, Ulla G. (2024). Characterization of intestinal O-glycome in reactive oxygen species deficiency. PLOS ONE. Vol. 19.

Bechtella, Leïla; Chunsheng, Jin; Fentker, Kerstin; Ertürk, Güney R.; Safferthal, Marc; Polewski, Łukasz; Götze, Michael; Graeber, Simon Y.; Vos, Gaël M.; Struwe, Weston B.; Mall, Marcus A.; Mertins, Philipp; Karlsson, Niclas ; Pagel, Kevin (2024). Ion mobility-tandem mass spectrometry of mucin-type O-glycans. Nature Communications. Vol. 15.

Elsaid, Khaled; Merriman, Tony R.; Rossitto, Leigh-Ana; Liu-Bryan, Ru; Karsh, Jacob; Phipps-Green, Amanda; Jay, Gregory D.; Elsayed, Sandy; Qadri, Marwa; Miner, Marin; Cadzow, Murray; Dambruoso, Talia J.; Schmidt, Tannin A.; Dalbeth, Nicola; Chhana, Ashika; Höglund, Jennifer; Ghassemian, Majid; Campeau, Anaamika; Maltez, Nancy; Karlsson, Niclas ; Gonzalez, David J.; Terkeltaub, Robert (2023). Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia. Arthritis & Rheumatology. Vol. 75.

De Marco Verissimo, Carolina; Cwiklinski, Krystyna; Nilsson, Jonas; Mirgorodskaya, Ekaterina; Jin, Chunsheng; Karlsson, Niclas ; Dalton, John P. (2023). Glycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica. Molecular & Cellular Proteomics. Vol. 22.

Andersson, Elin; Tykesson, Emil; Lohmander, L. Stefan; Karlsson, Niclas ; Jin, Chunsheng; Mirgorodskaya, Ekaterina; Swärd, Per; Struglics, André (2023). Quantification of chondroitin sulfate, hyaluronic acid and N-glycans in synovial fluid – A technical performance study. Osteoarthritis and Cartilage Open. Vol. 5.

Contessotto, Paolo; Spelat, Renza; Ferro, Federico; Vysockas, Vaidas; Krivickienė, Aušra; Jin, Chunsheng; Chantepie, Sandrine; Chinello, Clizia; Pauza, Audrys G.; Valente, Camilla; Rackauskas, Mindaugas; Casara, Alvise; Zigmantaitė, Vilma; Magni, Fulvio; Papy-Garcia, Dulce; Karlsson, Niclas ; Ereminienė, Eglė; Pandit, Abhay; Da Costa, Mark (2023). Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model. 16 p. Nature Communications. Vol. 14.

Chahal, Gurdeep; Padra, Médea; Erhardsson, Mattias; Jin, Chunsheng; Quintana-Hayashi, Macarena; Venkatakrishnan, Vignesh; Padra, János Tamás; Stenbäck, Helen; Thorell, Anders; Karlsson, Niclas ; Lindén, Sara K. (2022). A Complex Connection Between the Diversity of Human Gastric Mucin O-Glycans, Helicobacter pylori Binding, Helicobacter Infection and Fucosylation. Molecular & Cellular Proteomics. Vol. 21.

Huang, Shan; Thomsson, Kristina A.; Jin, Chunsheng; Ryberg, Henrik; Das, Nabangshu; Struglics, André; Rolfson, Ola; Björkman, Lena I.; Eisler, Thomas; Schmidt, Tannin A.; Jay, Gregory D.; Krawetz, Roman; Karlsson, Niclas (2022). Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines. Frontiers in Molecular Biosciences. Vol. 9.

Luis, Ana S; Baslé, Arnaud; Byrne, Dominic P.; Wright, Gareth S. A.; London, James A.; Jin, Chunsheng; Karlsson, Niclas ; Hansson, Gunnar C.; Eyers, Patrick A.; Czjzek, Mirjam; Barbeyron, Tristan; Yates, Edwin A.; Martens, Eric C.; Cartmell, Alan (2022). Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. 8 p. Nature Chemical Biology. Vol. 18.

Kouka, Thukaa; Akase, Sachiko; Sogabe, Isami; Jin, Chunsheng; Karlsson, Niclas ; Aoki-Kinoshita, Kiyoko F. (2022). Computational Modeling of O-Linked Glycan Biosynthesis in CHO Cells. Molecules. Vol. 27.

These publications are obtained from Cristin. The list may be incomplete