Kort om
Professor Niclas Karlssons forskning fokuserer på rollen til glykosylering i menneskers helse. Glykaner er allestedsnærværende i biologiske grensesnitt, inkludert glykokalyx på cellemembraner, på slimhinneoverflater som beskytter mage-tarm-, lunge- og reproduktive kanaler og leddene i muskelskjelettsystemet. Gruppen bruker state-of-the-art massespektrometrisk og HPLC-basert glykomikk og glykoproteomikk av både N-linked og O-linked glykoproteiner for å identifisere patologisk endring av glykosyleringen.
Databaser:
UniCarb-DB (https://unicarb-db.expasy.org)
UniCarb-DR (https://unicarb-dr.glycosmos.org).
Publikationer:
Pubmed (https://www.ncbi.nlm.nih.gov/myncbi/1-Wzd4_y7_JkD/bibliography/public/)
Twitter: UniCarb-DB@NG_Karlsson
Forskningsgrupper
Publikasjoner og forskningsresultater
Vitenskapelige publikasjoner
Andersson, Elin; Tykesson, Emil; Lohmander, L. Stefan; Karlsson, Niclas; Jin, Chunsheng; Mirgorodskaya, Ekaterina; Swärd, Per; Struglics, André (2023). Quantification of chondroitin sulfate, hyaluronic acid and N-glycans in synovial fluid – A technical performance study. Osteoarthritis and Cartilage Open . Vol. 5.
Contessotto, Paolo; Spelat, Renza; Ferro, Federico; Vysockas, Vaidas; Krivickienė, Aušra; Jin, Chunsheng; Chantepie, Sandrine; Chinello, Clizia; Pauza, Audrys G.; Valente, Camilla; Rackauskas, Mindaugas; Casara, Alvise; Zigmantaitė, Vilma; Magni, Fulvio; Papy-Garcia, Dulce; Karlsson, Niclas; Ereminienė, Eglė; Pandit, Abhay; Da Costa, Mark (2023). Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model. Nature Communications . Vol. 14.
Chahal, Gurdeep; Padra, Médea; Erhardsson, Mattias; Jin, Chunsheng; Quintana-Hayashi, Macarena; Venkatakrishnan, Vignesh; Padra, János Tamás; Stenbäck, Helen; Thorell, Anders; Karlsson, Niclas; Lindén, Sara K. (2022). A Complex Connection Between the Diversity of Human Gastric Mucin O-Glycans, Helicobacter pylori Binding, Helicobacter Infection and Fucosylation. Molecular & Cellular Proteomics . Vol. 21.
Huang, Shan; Thomsson, Kristina A.; Jin, Chunsheng; Ryberg, Henrik; Das, Nabangshu; Struglics, André; Rolfson, Ola; Björkman, Lena I.; Eisler, Thomas; Schmidt, Tannin A.; Jay, Gregory D.; Krawetz, Roman; Karlsson, Niclas (2022). Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines. Frontiers in Molecular Biosciences . Vol. 9.
Luis, Ana S; Baslé, Arnaud; Byrne, Dominic P.; Wright, Gareth S. A.; London, James A.; Jin, Chunsheng; Karlsson, Niclas; Hansson, Gunnar C.; Eyers, Patrick A.; Czjzek, Mirjam; Barbeyron, Tristan; Yates, Edwin A.; Martens, Eric C.; Cartmell, Alan (2022). Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Nature Chemical Biology . Vol. 18.
Kouka, Thukaa; Akase, Sachiko; Sogabe, Isami; Jin, Chunsheng; Karlsson, Niclas; Aoki-Kinoshita, Kiyoko F. (2022). Computational Modeling of O-Linked Glycan Biosynthesis in CHO Cells. Molecules . Vol. 27.
Wilkinson, Hayden; Thomsson, Kristina A.; Rebelo, Ana L.; Hilliard, Mark; Pandit, Abhay; Rudd, Pauline M.; Karlsson, Niclas; Saldova, Radka (2021). The O-Glycome of Human Nigrostriatal Tissue and Its Alteration in Parkinson's Disease. Journal of Proteome Research . Vol. 20.
Mateoui, Constantina; Vitiazeva, Varvara; Kristjansdottir, Björg; Weijdegård, Birgitta; Örnros, Jessica; Gallini, Radiosa; Kamali-Moghaddam, Masood; Sundfeldt, Karrin; Karlsson, Niclas (2021). Analysis of blood group antigens on MUC5AC in mucinous ovarian cancer tissues using in situ proximity ligation assay. Glycobiology . Vol. 31.
Aoki-Kinoshita, Kiyoko F.; Lisacek, Frederique; Karlsson, Niclas; Kolarich, Daniel; Packer, Nicolle H. (2021). GlycoBioinformatics. Beilstein Journal of Organic Chemistry . Vol. 17.
Thomsson, Kristina A.; Vitiazeva, Varvara; Mateoiu, Constantina; Jin, Chunsheng; Liu, Jining; Holgersson, Jan; Weijdegård, Birgitta; Sundfeldt, Karin; Karlsson, Niclas (2021). Sulfation of O-glycans on mucin-type proteins from serous ovarian epithelial tumors. 17 s. Molecular & Cellular Proteomics . Vol. 20.
