English version
Niclas Karlsson

Niclas Karlsson

Kort om

Professor Niclas Karlssons forskning fokuserer på rollen til glykosylering i menneskers helse. Glykaner er allestedsnærværende i biologiske grensesnitt, inkludert glykokalyx på cellemembraner, på slimhinneoverflater som beskytter mage-tarm-, lunge- og reproduktive kanaler og leddene i muskelskjelettsystemet. Gruppen bruker state-of-the-art massespektrometrisk og HPLC-basert glykomikk og glykoproteomikk av både N-linked og O-linked glykoproteiner for å identifisere patologisk endring av glykosyleringen.

Databaser:

UniCarb-DB (https://unicarb-db.expasy.org)

UniCarb-DR (https://unicarb-dr.glycosmos.org).

Publikationer:

Pubmed (https://www.ncbi.nlm.nih.gov/myncbi/1-Wzd4_y7_JkD/bibliography/public/)

Twitter: UniCarb-DB@NG_Karlsson

Publikasjoner og forskningsresultater

Vitenskapelige publikasjoner

Rustad, Cecilie F.; Backe, Paul Hoff; Jin, Chunsheng; Merckoll, Else; Tveten, Kristian; Maciej-Hulme, Marissa Lucy ; Karlsson, Niclas ; Prescott, Trine; Mørk Sandås, Elise; Woldseth, Berit; Elgstøen, Katja B. Prestø; Holla, Øystein Lunde (2024). A monoallelic UXS1 variant associated with short-limbed short stature. Molecular Genetics & Genomic Medicine. Vol. 12.
https://doi.org/10.1002/mgg3.2472

Urban, James; Jin, Chunsheng; Thomsson, Kristina A.; Karlsson, Niclas ; Ives, Callum M.; Fadda, Elisa; Bojar, Daniel (2024). Predicting glycan structure from tandem mass spectrometry via deep learning. 9 s. Nature Methods. Vol. 21.
https://doi.org/10.1038/s41592-024-02314-6

Jin, Chunsheng; Venkatakrishnan, Vignesh; Thomsson, Kristina A.; Aoki, Nobuyuki P.; Shinmachi, Daisuke; Aoki-Kinoshita, Kiyoko F.; Hayes, Catherine A.; Lisacek, Frédérique; Karlsson, Niclas (2024). UniCarb-DB: An MS/MS Experimental Glycomic Fragmentation Database. 19 s. Methods in molecular biology. Vol. 2836.
https://doi.org/10.1007/978-1-0716-4007-4_6

Swisa, Avital; Kieckhaefer, Julia; Daniel, Scott G.; El-Mekkoussi, Hilana; Kolev, Hannah M.; Tigue, Mark; Jin, Chunsheng; Assenmacher, Charles-Antoine; Dohnalová, Lenka; Thaiss, Christoph A.; Karlsson, Niclas ; Bittinger, Kyle; Kaestner, Klaus H. (2024). The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation. Developmental Cell.
https://doi.org/10.1016/j.devcel.2024.05.006

Saldova, Radka; Thomsson, Kristina A.; Wilkinson, Hayden; Chatterjee, Maitrayee; Singh, Ashish K.; Karlsson, Niclas ; Knaus, Ulla G. (2024). Characterization of intestinal O-glycome in reactive oxygen species deficiency. PLOS ONE. Vol. 19.
https://doi.org/10.1371/journal.pone.0297292

Bechtella, Leïla; Chunsheng, Jin; Fentker, Kerstin; Ertürk, Güney R.; Safferthal, Marc; Polewski, Łukasz; Götze, Michael; Graeber, Simon Y.; Vos, Gaël M.; Struwe, Weston B.; Mall, Marcus A.; Mertins, Philipp; Karlsson, Niclas ; Pagel, Kevin (2024). Ion mobility-tandem mass spectrometry of mucin-type O-glycans. Nature Communications. Vol. 15.
https://doi.org/10.1038/s41467-024-46825-4

Acharya, Binayak; Tofthagen, Marthe ; Maciej-Hulme, Marissa Lucy ; Suissa, Michal Rachel; Karlsson, Niclas (2024). Limited support for a direct connection between prebiotics and intestinal permeability – a systematic review. Glycoconjugate Journal.
https://doi.org/10.1007/s10719-024-10165-8

Andersson, Elin; Tykesson, Emil; Lohmander, L. Stefan; Karlsson, Niclas ; Jin, Chunsheng; Mirgorodskaya, Ekaterina; Swärd, Per; Struglics, André (2023). Quantification of chondroitin sulfate, hyaluronic acid and N-glycans in synovial fluid – A technical performance study. Osteoarthritis and Cartilage Open. Vol. 5.
https://doi.org/10.1016/j.ocarto.2023.100380

Contessotto, Paolo; Spelat, Renza; Ferro, Federico; Vysockas, Vaidas; Krivickienė, Aušra; Jin, Chunsheng; Chantepie, Sandrine; Chinello, Clizia; Pauza, Audrys G.; Valente, Camilla; Rackauskas, Mindaugas; Casara, Alvise; Zigmantaitė, Vilma; Magni, Fulvio; Papy-Garcia, Dulce; Karlsson, Niclas ; Ereminienė, Eglė; Pandit, Abhay; Da Costa, Mark (2023). Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model. 16 s. Nature Communications. Vol. 14.
https://doi.org/10.1038/s41467-023-36350-1

De Marco Verissimo, Carolina; Cwiklinski, Krystyna; Nilsson, Jonas; Mirgorodskaya, Ekaterina; Jin, Chunsheng; Karlsson, Niclas ; Dalton, John P. (2023). Glycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica. Molecular & Cellular Proteomics. Vol. 22.
https://doi.org/10.1016/j.mcpro.2023.100684





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