Affiliation
Research projects
Completed research projects
Artificial intelligence – a novel tool in assisted reproduction technology
The project aims to improve the methods for selecting sperm and embryos and increase the chance of pregnancy and live-born children.
Artificial intelligence - a novel tool in assisted reproduction technology
The project aims to improve the methods for selecting sperm and embryos and increase the chance of pregnancy and live-born children.
Publications and research
Scientific publications (22)
- Kakulavarapu, Radhika; Delbarre, Erwan; Sharma, Akriti; Jahanlu, David; Riegler, Michael Alexander; Haugen, Trine B.; Iliceto, Mario; Stensen, Mette Haug (2026). Investigating discrepancies in accuracy, agreement and interpretability for single-frame embryo classification tasks conducted by embryologists and deep learning models. Frontiers in Reproductive Health. Vol. 8
- Sharma, Akriti; Dorobantiu, Alexandru; Ali, Saquib; Iliceto, Mario; Stensen, Mette Haug; Delbarre, Erwan; Riegler, Michael; Hammer, Hugo Lewi (2025). Deep learning methods to forecasting human embryo development in time-lapse videos. PLOS ONE. Vol. 20
- Kakulavarapu, Radhika; Stensen, Mette Haug; Jahanlu, David; Haugen, Trine B.; Delbarre, Erwan (2023). Altered morphokinetics and differential reproductive outcomes associated with cell exclusion events in human embryos. Reproductive Biomedicine Online. Vol. 47
- Sharma, Akriti; Stensen, Mette Haug; Delbarre, Erwan; Haugen, Trine; Hammer, Hugo Lewi (2022). Explainable Artificial Intelligence for Human Embryo Cell Cleavage Stages Analysis. Dao, Minh-Son (Ed.). ICDAR '22: Proceedings of the 3rd ACM Workshop on Intelligent Cross-Data Analysis and Retrieval. Association for Computing Machinery (ACM)
- Riegler, Michael Alexander; Stensen, Mette Haug; Witczak, Oliwia; Andersen, Jorunn Marie; Hicks, Steven; Hammer, Hugo Lewi; Delbarre, Erwan; Halvorsen, Pål; Yazidi, Anis; Holst, Nicolai; Haugen, Trine B. (2021). Artificial intelligence in the fertility clinic: status, pitfalls and possibilities. Human Reproduction. Vol. 36. p. 2429-2442
- Delbarre, Erwan; Janicki, Susan M (2021). Modulation of H3.3 chromatin assembly by PML: A way to regulate epigenetic inheritance. Bioessays. Vol. 43
- Paulsen, Jonas; Ali, Tharvesh Moideen Liyakat; Nekrasov, Maxim; Delbarre, Erwan; Baudement, Marie-Odile; Kurscheid, Sebastian; Tremethick, David; Collas, Philippe (2019). Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation. Nature Genetics. Vol. 51. p. 835-843
- Spirkoski, Jane; Shah, Akshay; Reiner, Andrew Henry; Collas, Philippe; Delbarre, Erwan (2019). PML modulates H3.3 targeting to telomeric and centromeric repeats in mouse fibroblasts. Biochemical and Biophysical Research Communications - BBRC. Vol. 511. p. 882-888
- Zink, Lisa-Maria; Delbarre, Erwan; Eberl, H Christian; Keilhauer, Eva C; Bonisch, Clemens; Punzeler, Sebastian; Bartkuhn, Marek; Collas, Philippe; Mann, Matthias; Hake, Sandra B. (2017). H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements. Nucleic Acids Research (NAR). Vol. 45. p. 5691-5706
- Delbarre, Erwan; Ivanauskiene, Kristina; Spirkoski, Jane; Shah, Akshay; Vekterud, Kristin; Moskaug, Jan Øivind; Bøe, Stig Ove; Wong, Lee H.; Küntziger, Thomas M.; Collas, Philippe (2017). PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX. Genome Research. Vol. 27. p. 913-921
- Paulsen, Jonas; Sekelja, Monika; Oldenburg, Anja; Barateau, Alice; Briand, Nolwenn; Delbarre, Erwan; Shah, Akshay; Sørensen, Anita Løvstad; Vigouroux, Corinne; Buendia, Brigitte; Collas, Philippe (2017). Chrom3D: Three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts. Genome Biology. Vol. 18:21. p. 1-15
- Lund, Eivind Gard; Collas, Philippe; Delbarre, Erwan (2015). Transcription outcome of promoters enriched in histone variant h3.3 defined by positioning of H3.3 and local chromatin marks. Biochemical and Biophysical Research Communications - BBRC. Vol. 460. p. 345-353
- Rønningen, Torunn; Shah, Akshay; Oldenburg, Anja; Vekterud, Kristin; Delbarre, Erwan; Moskaug, Jan Øivind; Collas, Philippe (2015). Prepatterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B. Genome Research. Vol. 25. p. 1825-1835
- Ivanauskiene, Kristina; Delbarre, Erwan; McGhie, James; Küntziger, Thomas Michel; Wong, Lee-Jun C.; Collas, Philippe (2014). The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity. Genome Research. Vol. 24. p. 1584-1594
- Ruppelt, Anja Oldenburg; Delbarre, Erwan; Thiede, Bernd; Vigouroux, Corinne; Collas, Philippe (2013). Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes. Human Molecular Genetics. Vol. 23. p. 1151-1162
- Lund, Eivind Gard; Ruppelt, Anja Oldenburg; Delbarre, Erwan; Freberg, Christel Taranger; Duband-Goulet, Isabelle; Eskeland, Ragnhild; Buendia, Brigitte; Collas, Philippe (2013). Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Research. Vol. 23. p. 1580-1589
- Delbarre, Erwan; Ivanauskiene, Kristina; Küntziger, Thomas Michel; Collas, Philippe (2013). DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin. Genome Research. Vol. 23. p. 440-451
- Bruston, Francine; Delbarre, Erwan; Östlund, Cecilia; Worman, Howard J; Buendia, B; Duband-Goulet, Isabelle (2010). Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin. FEBS Letters. Vol. 584. p. 2999-3004
- Delbarre, Erwan; Jacobsen, Bente Marie Berntsen; Reiner, Andrew Henry; Sørensen, Anita Løvstad; Kuntziger, Thomas Michel; Collas, Philippe (2010). Chromatin Environment of Histone Variant H3.3 Revealed by Quantitative Imaging and Genome-scale Chromatin and DNA Immunoprecipitation. Molecular Biology of the Cell. Vol. 21. p. 1872-1884
- Faureau, C; Delbarre, Erwan; Courvalin, JC; Buendia, B (2008). Differentiation of C2C12 myoblasts expressing lamin A mutated at a site responsible for Emery-Dreifuss muscular dystrophy is improved by inhibition of the MEK-ERK pathway and stimulation of the PI3-kinase pathway. Experimental Cell Research. Vol. 314
- Håkelien, Anne-Mari; Delbarre, Erwan; Gaustad, Kristine Gjul; Buendia, B; Collas, Philippe (2008). Expression of the myodystrophic R453W mutation of lamin A in C2C12 myoblasts causes promoter-specific and global epigenetic defects. Experimental Cell Research. Vol. 314. p. 1869-1880
- Delbarre, Erwan; Tramier, Marc; Coppey-Moisan, Maïté; Gaillard, Claire; Courvalin, Jean-Claude; Buendia, Brigitte (2006). The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers. Human Molecular Genetics. Vol. 15. p. 1113-1122
Research reports (1)
- Hammer, Hugo Lewi; Riegler, Michael Alexander; Delbarre, Erwan; Stensen, Mette Haug; Sharma, Akriti (2025). Application of Artificial Intelligence in Assisted Reproductive Technology. 243 p.. OsloMet - storbyuniversitetet
Dissemination (14)
- Aas, Ingvild; Halvorsen, Pia S.; Stensen, Mette Haug; Due, Eldri Undlien; Haugen, Trine B.; Witczak, Oliwia; Delbarre, Erwan (2023). Direct visualization of DNA breaks in human sperm using an in situ DNA end-labelling approach. 22nd European Testis Workshop
- Sharma, Akriti; Stensen, Mette; Delbarre, Erwan; Siddiqui, Momin; Haugen, Trine; Riegler, Michael; Hammer, Hugo (2023). Detecting human embryo cleavage stages using YOLO v5 object detection algorithm. Nordic Artificial Intelligence Research and Development
- Delbarre, Erwan (2023). Evaluation of deep learning models for cell cleavage classification. Workshop in Spermatology
- Kakulavarapu, Radhika; Stensen, Mette Haug; Haugen, Trine B.; Delbarre, Erwan (2022). P-136 Cell exclusion during human embryo development results in altered morphokinetic patterns up to morula formation. Human Reproduction. Vol. 37
- Sharma, Akriti; Kakulavarapu, Radhika; Thambawita, Vajira L B; Siddiqui, M.; Delbarre, Erwan; Riegler, Michael; Hammer, Hugo Lewi; Stensen, Mette Haug (2022). Automating tracking of cell division for human embryo development in time lapse videos. Human Reproduction. Vol. 37
- Delbarre, Erwan; Stensen, Mette Haug (2022). Kunstig intelligens i en fertilitetsklinikk: elsk eller hat?. Norsk forening for assistert befruktning
- Delbarre, Erwan; Olsen, Lisbeth Charlotte; Haugen, Trine B. (2020). What is good semen quality - still an open question. NBS-nytt. Vol. 1. p. 12-12
- Ivanauskiene, Kristina; Delbarre, Erwan; Küntziger, Thomas Michel; Collas, Philippe (2012). DAXX-dependent recruitment of histone variant H3.3 to PML bodies before deposition into chromatin. The FEBS Journal. Vol. 279. p. 505-505
- Collas, Philippe; Delbarre, Erwan; Küntziger, Thomas Michel; Lund, Eivind Gard; Ruppelt, Anja; Reiner, Andrew Henry; Sørensen, Anita Løvstad (2012). Epigenetic programming of stromal cell fate. International Journal of Molecular Medicine. Vol. 30. p. S57-S57
- Delbarre, Erwan; Jacobsen, Bente Marie Berntsen; Kuntziger, Thomas Michel; Collas, Philippe (2009). Epigenetic environment of the histone variant H3.3 revealed by integration of imaging and genome-scale ChIP information. EMBO conference series on nuclear structure and dynamics
- Jacobsen, Bente Marie Berntsen; Delbarre, Erwan; Collas, Philippe (2009). The histone variant H3.3 associates with transcriptionally active chromatin: integration of imaging and ChIP-on-chip approaches. Second FUGE Retreat
- Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel; Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations. 20th Wilhelm Bernhard Workshop on the Cell Nucleus
- Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel; Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations. International Society for Stem Cell Research annual meeting
- Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel; Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations. Keystone symposium
These publications are obtained from Norwegian Research Information Repository. The list may be incomplete.