Research groups
Research projects
Ongoing research projects
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Personalized treatment – TDM and pharmacogenetics
This project is an assessment of variation in exposure and response to psychoactive drugs.
Publications and research
Scientific publications
Hole, Kristine
; Molden, Espen
(2025).
Association Between CYP2D6 Genotypes and Serum Concentrations of Mirtazapine and Mianserin.
Basic & Clinical Pharmacology & Toxicology.
Vol. 136.
https://doi.org/10.1111/bcpt.70013
Larsen, Rønnaug;
Hole, Kristine
; Selle, Maria;
Landmark, Cecilie Johannessen
;
Krogstad, Tonje
;
Holm, Lene Berge
(2024).
Access to a tailored mobile application enhances medication adherence among young users of antidepressants.
11 p.
Frontiers in Pharmacology.
Vol. 15.
https://doi.org/10.3389/fphar.2024.1379700
Faraj, Pari;
Haslemo, Tore
; Tran, Jenny Phung; Stingl, Julia; Molden, Espen;
Hole, Kristine
(2024).
Combined effect of CYP2C19 and CYP2D6 genotypes on escitalopram serum concentration and its metabolic ratio in a European patient population.
British Journal of Clinical Pharmacology.
https://doi.org/10.1111/bcp.16156
Hole, Kristine
; Lorentsen, Silje K.; Nordby, Karoline L; Slettvik, Marie; Sørum, Ida T. G.; Molden, Espen;
Haslemo, Tore
(2024).
Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets.
European Journal of Clinical Pharmacology.
https://doi.org/10.1007/s00228-024-03655-z
Tveit, Kristine; Hermann, Monica; Nilsen, Roy Miodini; Wallerstedt, Susanna M.; Rongve, Arvid; Molden, Espen;
Hole, Kristine
(2024).
Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals.
European Journal of Clinical Pharmacology.
Vol. 80.
https://doi.org/10.1007/s00228-023-03611-3
Hole, Kristine
; Gangsø, Sofie; Jensstuen, Åse Tonette; Ormøy, Hanne Holte; Paulsen, Maren; Molden, Espen;
Haslemo, Tore
(2023).
Effect of CYP2D6 genotype on duloxetine serum concentration.
Basic & Clinical Pharmacology & Toxicology.
Vol. 134.
https://doi.org/10.1111/bcpt.13954
Hole, Kristine
;
Haslemo, Tore
; Molden, Espen
(2023).
Impact of CYP2D6 Genotype on Paroxetine Serum Concentration.
5 p.
Therapeutic Drug Monitoring.
Vol. 45.
https://doi.org/10.1097/FTD.0000000000001096
Faraj, Pari; Størset, Elisabet;
Hole, Kristine
; Smith, Godfrey L; Molden, Espen; Dietrichs, Erik Sveberg
(2023).
Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients.
10 p.
EBioMedicine.
Vol. 95.
https://doi.org/10.1016/j.ebiom.2023.104779
Faraj, Pari; Hermansen, Astrid; Molden, Espen;
Hole, Kristine
(2022).
Identification of Escitalopram Metabolic Ratios as Potential Biomarkers for Predicting CYP2C19 Poor Metabolizers.
8 p.
Therapeutic Drug Monitoring.
Vol. 44.
https://doi.org/10.1097/FTD.0000000000000991
Kvitne, Kine Eide;
Hole, Kristine
; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine; Johnson, Line Kristin; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Åsberg, Anders; Molden, Espen; Robertsen, Ida
(2022).
Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range.
10 p.
European Journal of Clinical Pharmacology.
Vol. 78.
https://doi.org/10.1007/s00228-022-03336-9
