Forskningsgrupper
Forskningsprosjekter
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Persontilpassa legemiddelbehandling – legemiddelanalysar og farmakogenetikk
Dette prosjektet er ei kartlegging av variasjon i eksponering og respons av psykofarmakum.
Publikasjoner og forskningsresultater
Vitenskapelige publikasjoner
Hole, Kristine
; Gangsø, Sofie; Jensstuen, Åsa Tonette; Ormøy, Hanne Holte; Paulsen, Maren; Molden, Espen;
Haslemo, Tore
(2023).
Effect of CYP2D6 genotype on duloxetine serum concentration.
Basic & Clinical Pharmacology & Toxicology.
https://doi.org/10.1111/bcpt.13954
Hole, Kristine
;
Haslemo, Tore
; Molden, Espen
(2023).
Impact of CYP2D6 Genotype on Paroxetine Serum Concentration.
5 s.
Therapeutic Drug Monitoring.
Vol. 45.
https://doi.org/10.1097/FTD.0000000000001096
Faraj, Pari; Størset, Elisabet;
Hole, Kristine
; Smith, Godfrey L; Molden, Espen; Dietrichs, Erik Sveberg
(2023).
Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients.
EBioMedicine.
Vol. 95.
https://doi.org/10.1016/j.ebiom.2023.104779
Faraj, Pari; Hermansen, Astrid; Molden, Espen;
Hole, Kristine
(2022).
Identification of Escitalopram Metabolic Ratios as Potential Biomarkers for Predicting CYP2C19 Poor Metabolizers.
8 s.
Therapeutic Drug Monitoring.
Vol. 44.
https://doi.org/10.1097/FTD.0000000000000991
Kvitne, Kine Eide;
Hole, Kristine
; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine; Johnson, Line Kristin; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Åsberg, Anders; Molden, Espen; Robertsen, Ida
(2022).
Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range.
10 s.
European Journal of Clinical Pharmacology.
Vol. 78.
https://doi.org/10.1007/s00228-022-03336-9
Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege Staaland; Krogstad, Veronica; Wegler, Christine; Angeles, Philip Carlo Soriano; Wollmann, Birgit Malene Tovik;
Hole, Kristine
; Johnson, Line Kristin; Sandbu, Rune; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesæth, Jøran; Jansson-Löfmark, Rasmus; Åsberg, Anders
(2021).
Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity – a non-randomized three-armed controlled trial.
13 s.
Clinical and Translational Science (CTS).
https://doi.org/10.1111/cts.13142
Hole, Kristine
; Arnestad, Marianne; Molden, Espen;
Haslemo, Tore
(2021).
Dose-Dependent Inhibition of CYP2D6 by Bupropion in Patients with Depression.
4 s.
Journal of Clinical Psychopharmacology.
Vol. 41.
https://doi.org/10.1097/JCP.0000000000001387
Klaasen, Rolf; Bergan, Stein; Bremer, Sara;
Hole, Kristine
; Nordahl, Christine Berg; Andersen, Anders Mikal; Midtvedt, Karsten; Skauby, Morten Heier; Vethe, Nils Tore
(2020).
Pharmacodynamic assessment of mycophenolic acid in resting and activated target cell population during the first year after renal transplantation.
British Journal of Clinical Pharmacology.
Vol. 86.
https://doi.org/10.1111/bcp.14218
Gjestad, Caroline;
Hole, Kristine
;
Haslemo, Tore
; Diczfalusy, Ulf; Molden, Espen
(2019).
Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol—an Interaction Study in Healthy Volunteers.
7 s.
AAPS Journal.
Vol. 21.
https://doi.org/10.1208/s12248-019-0330-1
Hole, Kristine
; Wollmann, Birgit Malene Tovik; Nguyen, Camilla;
Haslemo, Tore
; Molden, Espen
(2018).
Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker.
Therapeutic Drug Monitoring.
Vol. 40.
https://doi.org/10.1097/FTD.0000000000000518