Forskningsgrupper
Forskningsprosjekter
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Persontilpassa legemiddelbehandling – legemiddelanalysar og farmakogenetikk
Dette prosjektet er ei kartlegging av variasjon i eksponering og respons av psykofarmakum.
Publikasjoner og forskningsresultater
Vitenskapelige publikasjoner
Størset, Elisabet; Bråten, Line Skute; Ingelman-Sundberg, Magnus; Johansson, Inger; Molden, Espen;
Kringen, Marianne K.
(2024).
Impact of CYP2D6*2, CYP2D6*35, rs5758550, and related haplotypes on risperidone clearance in vivo.
European Journal of Clinical Pharmacology.
https://doi.org/10.1007/s00228-024-03721-6
Chalabianloo, Fatemeh; Fadnes, Lars T.; Johansson, Kjell Arne; Høiseth, Gudrun; Vold, Jørn Henrik;
Kringen, Marianne K.
; Spigset, Olav; Bramness, Jørgen Gustav
(2024).
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications.
Basic & Clinical Pharmacology & Toxicology.
Vol. 134.
https://doi.org/10.1111/bcpt.13975
Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Størset, Elisabet; Lenk, Hasan Cagin; O'Connell, Kevin S.;
Kringen, Marianne K.
; Ingelman-Sundberg, Magnus; Molden, Espen
(2024).
Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.
Clinical and Translational Science (CTS).
Vol. 17.
https://doi.org/10.1111/cts.13743
Muriel, J.; Escorial, M.; Carratalá, C.; Margarit, C.; Barrachina, J.; López, A.; Gallardo, E.;
Kringen, Marianne K.
; Peiró, A.M.
(2024).
Use of CYP2D6 substrates and inhibitors during pain management with analgesic opioids: Drug-drug interactions that lead to lack of analgesic effectiveness.
Biomedicine & Pharmacotherapy.
Vol. 176.
https://doi.org/10.1016/j.biopha.2024.116882
Wollmann, Birgit Malene Tovik; Størset, Elisabet;
Kringen, Marianne K.
; Molden, Espen; Smith, Robert Løvsletten
(2023).
Prediction of CYP2D6 poor metabolizers by measurements of solanidine and metabolites—a study in 839 patients with known CYP2D6 genotype.
8 s.
European Journal of Clinical Pharmacology.
Vol. 79.
https://doi.org/10.1007/s00228-023-03462-y
Hovd, Markus Herberg; Robertsen, Ida; Johnson, Line Kristin; Krogstad, Veronica; Wegler, Christine; Kvitne, Kine Eide;
Kringen, Marianne K.
; Skovlund, Eva; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Sandbu, Rune; Hjelmesæth, Jøran Sture; Åsberg, Anders; Jansson-Löfmark, Rasmus; Christensen, Hege
(2023).
Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance.
Clinical Pharmacokinetics.
Vol. 62.
https://doi.org/10.1007/s40262-023-01235-5
Wollmann, Birgit Malene Tovik; Smith, Robert Løvsletten;
Kringen, Marianne K.
; Ingelman-Sundberg, Magnus; Molden, Espen; Størset, Elisabet
(2023).
Evidence for solanidine as a dietary CYP2D6 biomarker: Significant correlation with risperidone metabolism.
British Journal of Clinical Pharmacology.
https://doi.org/10.1111/bcp.15721
Solhaug, Vigdis;
Haslemo, Tore
;
Kringen, Marianne Kristiansen
; Molden, Espen; Dietrichs, Erik Sveberg
(2022).
Genotyping av pasienter behandlet med selektive serotoninreopptakshemmere.
9 s.
Tidsskrift for Den norske legeforening.
Vol. 142.
https://doi.org/10.4045/tidsskr.22.0017
Chalabianloo, Fatemeh; Høiseth, Gudrun; Vold, Jørn Henrik; Johansson, Kjell Arne;
Kringen, Marianne K.
; Dalgard, Olav; Ohldieck, Christian; Druckrey-Fiskaaen, Karl Trygve; Aas, Christer Frode; Løberg, Else-Marie; Bramness, Jørgen Gustav; Fadnes, Lars T.
(2022).
Impact of liver fibrosis and clinical characteristics on dose-adjusted serum methadone concentrations.
11 s.
Journal of Addictive Diseases.
Vol. 41.
https://doi.org/10.1080/10550887.2022.2057140
Halvorsen, Lene Vernås; Bergland, Ola Undrum; Søraas, Camilla Lund;
Larstorp, Anne Cecilie Kjeldsen
; Hjørnholm, Ulla; Kjær, Vibeke Norheim;
Kringen, Marianne K.
; Clasen, Per-Erik; Haldsrud, Renate; Kjeldsen, Sverre; Rostrup, Morten; Fadl Elmula, Fadl Elmula M.; Opdal, Mimi Stokke; Høieggen, Aud
(2022).
Nonadherence by Serum Drug Analyses in Resistant Hypertension: 7-Year Follow-Up of Patients Considered Adherent by Directly Observed Therapy.
Journal of the American Heart Association (JAHA).
Vol. 11.
https://doi.org/10.1161/JAHA.121.025879